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A breakthrough technology rarely wins because the invention looks impressive. A breakthrough wins
when it makes a costly form of coordination cheap. I’m a student of history, especially the transformative effects of disease and technology on how societies and commerce function. I read many posts on LinkedIn discussing Agentic AI and there is considerable handwringing in some of those posts. Taking a look at history, I suggest the adoption pattern for Agentic AI will be similar. Transportation (canals, railroads, cars, fiber optics) provide a clean reference case for what happens when a technology reduces friction in moving value across distance. Canals illustrate the pattern Canals mattered because they turned water movement into controlled flow. Water always moved, but canals added engineered controls and governance—locks, channels, rules, and tolls—that enabled steady, predictable freight transport across distance. That reliability reduced friction and lowered the effective cost of coordination. Industry reorganized around the new throughput. Commerce soon moved more per unit of time. Railroads repeated the pattern Railroads repeated the pattern with speed and reliability. They moved more per unit of time. Additionally, railroads had a knock-on effect. Rail wear made durability a requirement, not a preference. That demand helped scale steelmaking into mass production. Steel became available in high volume, on quick command that enabled many other infrastructure developments. Cars repeated the pattern again Mass-produced cars repeated the pattern with point-to-point mobility. Cars increased destinations per hour. Cars also changed the map of work because commuting time became a variable people could buy down. Fiber-optic cables repeated the pattern again Fiber-optic cables repeated the pattern with data bandwidth. Fiber increased information moved per unit of time and reduced latency. Early builders laid far more fiber than networks needed, so large stretches sat “dark”—installed but not lit—because demand had not caught up. As data traffic grew, operators lit that capacity and throughput rose without re-digging the ground. Global coordination became routine because distance had little to do with what was delivered per unit of time. Agentic AI belongs in the same category Agentic AI reduces time (and cost) of moving work across systems. Agents increase completed work per day by reducing handoff time between intent and action. Coordination work becomes cheaper than the work it supports. Regulatory writing provides a clear view of the shift. What becomes cheap Most regulatory teams do not suffer from a lack of expertise. Many teams suffer from expensive coordination. Coordination shows up as time spent:
The three-layer framework that predicts outcomes History suggests that durable transformations depend on three layers. 1) Infrastructure layer Canals needed locks, surveying, financing mechanisms, and governance. Agentic AI needs:
Canals needed schedules, toll rules, standards, and dispute handling. Agentic AI needs algorithms to define:
Canals reorganized commerce and rewarded the builders of complements. Agentic AI may reorganize regulatory work and reward teams that deliver:
Where we are right now Most organizations sit in an early “canal” phase: impressive boats, missing locks. Many teams are experimenting with generative drafting while the foundation remains weak:
A strong agentic approach begins with structure: define what the agent may access, what the agent may produce, and what a reviewer must be able to verify. What will likely happen next in regulatory writing Several shifts appear likely. 1) Value will migrate from prose to architecture Sponsors will pay less for “first drafts” and more for:
2) QA and governance will become differentiators Auditability will separate helpful systems from unsafe ones. A defensible workflow will require provenance, versioning, and repeatable checks. 3) Agent design will look like information design
The practical takeaway Canals did not replace judgment. Canals rewarded builders who reduced friction with consistent water flow and rules. Agentic AI will likely do the same. Teams that build the complements—provenance, workflow control, evaluation, and traceability—will define the next standard for decision-ready regulatory writing. Join the conversation on LinkedIn: https://www.linkedin.com/pulse/agentic-ai-feels-new-pattern-old-lessons-from-canals-writing-cuppan-fft1c
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AuthorGregory Cuppan is the Managing Principal of McCulley/Cuppan Inc., a group he co-founded. Mr. Cuppan has spent 30+ years working in the life sciences with 20+ years providing consulting and training services to pharmaceutical and medical device companies and other life science enterprises. Archives
December 2025
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